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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRKCA All Species: 34.55
Human Site: S226 Identified Species: 69.09
UniProt: P17252 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P17252 NP_002728.1 672 76764 S226 L N P Q W N E S F T F K L K P
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001096447 673 76980 T226 L N P E W N E T F R F Q L K E
Dog Lupus familis XP_548026 590 67545 K194 M P A S G W Y K L L N Q E E G
Cat Felis silvestris
Mouse Mus musculus P20444 672 76833 S226 L N P Q W N E S F T F K L K P
Rat Rattus norvegicus P05696 672 76773 S226 L N P Q W N E S F T F K L K P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510097 675 76844 S227 L N P Q W N E S F T F K L K P
Chicken Gallus gallus NP_001012822 674 76827 S226 L N P H W N E S F T F K L K P
Frog Xenopus laevis Q7LZQ8 671 76506 T223 L N P S W N E T F K F Q L K E
Zebra Danio Brachydanio rerio Q90XF2 588 67303 K213 P D Q V L G K K N S T E S I N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P05130 679 77676 T244 L N P V W N E T L T Y D L K P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P90980 682 77982 T229 L N P Q W N E T F T Y K L L P
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa P87253 1142 127954 S698 S I P D F G G S P G Y G R P D
Conservation
Percent
Protein Identity: 100 N.A. 80.2 86.7 N.A. 98.3 99.4 N.A. 97.1 93.9 78.4 34.6 N.A. 67.1 N.A. 66.4 N.A.
Protein Similarity: 100 N.A. 88.8 87.1 N.A. 98.8 99.6 N.A. 98.2 96.7 87 52.2 N.A. 80.7 N.A. 79.7 N.A.
P-Site Identity: 100 N.A. 66.6 0 N.A. 100 100 N.A. 100 93.3 66.6 0 N.A. 66.6 N.A. 80 N.A.
P-Site Similarity: 100 N.A. 86.6 20 N.A. 100 100 N.A. 100 93.3 80 26.6 N.A. 80 N.A. 93.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. 25.3
Protein Similarity: N.A. N.A. N.A. N.A. N.A. 38.3
P-Site Identity: N.A. N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 9 0 9 0 0 0 0 0 0 0 9 0 0 9 % D
% Glu: 0 0 0 9 0 0 75 0 0 0 0 9 9 9 17 % E
% Phe: 0 0 0 0 9 0 0 0 67 0 59 0 0 0 0 % F
% Gly: 0 0 0 0 9 17 9 0 0 9 0 9 0 0 9 % G
% His: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 9 0 0 0 0 0 0 0 0 0 0 0 9 0 % I
% Lys: 0 0 0 0 0 0 9 17 0 9 0 50 0 67 0 % K
% Leu: 75 0 0 0 9 0 0 0 17 9 0 0 75 9 0 % L
% Met: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 75 0 0 0 75 0 0 9 0 9 0 0 0 9 % N
% Pro: 9 9 84 0 0 0 0 0 9 0 0 0 0 9 59 % P
% Gln: 0 0 9 42 0 0 0 0 0 0 0 25 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 9 0 0 9 0 0 % R
% Ser: 9 0 0 17 0 0 0 50 0 9 0 0 9 0 0 % S
% Thr: 0 0 0 0 0 0 0 34 0 59 9 0 0 0 0 % T
% Val: 0 0 0 17 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 75 9 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 9 0 0 0 25 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _